The Journal of Emergency Medicine
Volume 37, Issue 4 , Pages 355-358 , November 2009

Contraindications to Phenytoin in Emergency Department Patients with Seizures

  • Robert Murphy, BS

      Affiliations

    • Emory University School of Medicine, Emory University, Atlanta, Georgia
    • ,
  • Jill Daugherty, MPH

      Affiliations

    • Department of Emergency Medicine, Emory University, Atlanta, Georgia
    • ,
  • Debra Houry, MD, MPH

      Affiliations

    • Department of Emergency Medicine, Emory University, Atlanta, Georgia
    • Corresponding Author InformationReprint Address: Debra Houry, md, mph, Emory University, 49 Jesse Hill Jr. Dr. SE #114, Atlanta, GA 30303

Received 20 February 2007 ,Revised 8 June 2007 ,Accepted 9 August 2007.

References 

  1. Slater J, Kalamangalam G. Epilepsy. In: ACP medicine online. 2007;www.acpmedicine.comAccessed January 18, 2007.
  2. Huff JS, Morris DL, Kothari RU, Gibbs MA Emergency Medicine Seizure Study Group. Emergency department management of patients with seizures: a multicenter study. Acad Emerg Med. 2001;8:622–628
  3. Jobst BC, Holmes GL. Prescribing antiepileptic drugs: should patients be switched on the basis of cost?. CNS Drugs. 2004;18:617–628
  4. Carpay JA, Aldenkamp AP, van Donselaar CA. Complaints associated with the use of antiepileptic drugs: results from a community-based study. Seizure. 2005;14:198–206
  5. Moran NF, Poole K, Bell G, et al. Epilepsy in the United Kingdom: seizure frequency and severity, anti-epileptic drug utilization and impact on life in 1652 people with epilepsy. Seizure. 2004;13:425–433
  6. Kjaer D, Horvath-Puho E, Christensen J, et al. Use of phenytoin, phenobarbital, or diazepam during pregnancy and risk of congenital abnormalities: a case-time-control study. Pharmacoepidemiol Drug Saf. 2007;16:181–188
  7. Adab N, Tudur SC, Vinten J, Williamson P, Winterbottom J. Common antiepileptic drugs in pregnancy in women with epilepsy. Cochrane Database Syst Rev. 2004;(3)::CD004848.
  8. Lacerda G, Krummel T, Sabourdy C, Ryvlin P, Hirsch E. Optimizing therapy of seizures in patients with renal or hepatic dysfunction. Neurology. 2006;67(Suppl 4):S28–S33
  9. Akula R, Hasan S, Pipalla R, Ferguson C. Noncompliance leading to drug accumulation resulting in phenytoin toxicity. J Natl Med Assoc. 2004;96:556–557
  10. Gilbert EH, Lowenstein SR, Koziol-McLain J, Barta DC, Steiner J. Chart reviews in emergency medicine: where are the methods?. Ann Emerg Med. 1996;27:305–308
  11. SPSS for Windows, Rel. 14.0; 2005. Chicago, IL. SPSS Inc.
  12. Committee on Identifying and Preventing Medication Errors. Prevention medication errors: quality chasm series. Washington, DC: National Academies Press; 2006;
  13. Swadron SP, Rudis MI, Azimian K, Beringer P, Fort D, Orlinsky M. A comparison of phenytoin-loading techniques in the emergency department. Acad Emerg Med. 2004;11:244–252

 This work was funded by UCB Pharma, Smyrna, GA.

PII: S0736-4679(07)00832-3

doi: 10.1016/j.jemermed.2007.08.067

The Journal of Emergency Medicine
Volume 37, Issue 4 , Pages 355-358 , November 2009

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