Standardization of Severe Sepsis Management: A Survey of Methodologies in Academic and Community Settings

Nguyen, H. Bryant; Oh, Jason; Otero, Ronny M.; Burroughs, Kristy; Wittlake, William A.; Corbett, Stephen W.

doi:10.1016/j.jemermed.2007.10.087

« Previous Next »The Journal of Emergency Medicine
Volume 38, Issue 2 , Pages 122-132, February 2010

Standardization of Severe Sepsis Management: A Survey of Methodologies in Academic and Community Settings

H. Bryant Nguyen, MD, MS
- Department of Emergency Medicine, Loma Linda University, Loma Linda, California
- Department of Medicine, Division of Pulmonary and Critical Care Medicine, Loma Linda University, Loma Linda, California
- Reprint Address: H. Bryant Nguyen, md, ms, Department of Emergency Medicine, Loma Linda University Medical Center, 11234 Anderson Street, Rm A108, Loma Linda, CA 92354
Jason Oh, MD
- Department of Emergency Medicine, University of Maryland, Baltimore, Maryland
Ronny M. Otero, MD
- Department of Emergency Medicine, Henry Ford Hospital, Detroit, Michigan
Kristy Burroughs, BS
- Department of Emergency Medicine, Loma Linda University, Loma Linda, California
William A. Wittlake, MD
- Department of Emergency Medicine, Loma Linda University, Loma Linda, California
Stephen W. Corbett, MD, PHD
- Department of Emergency Medicine, Loma Linda University, Loma Linda, California

Received 30 August 2007; received in revised form 10 October 2007; accepted 23 October 2007. published online 24 July 2008.

Abstract

Background: Evidence-based therapies for severe sepsis include early antibiotics, early goal-directed therapy, corticosteroids, recombinant human activated protein C, glucose control, and lung protective strategies. Objective: The objective of this study was to analyze methods, challenges, and outcomes observed by hospitals that implemented a hospital-wide sepsis management protocol incorporating evidence-based therapies. Methods: In a cross-sectional multi-center telephone survey over a 4-month period, clinicians (participants) responsible for developing a hospital sepsis protocol were questioned regarding its development and outcomes. Results: Participants completing surveys represented 40 hospitals (20 academic and 20 community). Twenty-seven percent of protocol champions were Emergency physicians or nurses. Sixty-three percent reported protocol development time of 6–12 months. Eighty-eight percent of participants reported protocol initiation in the Emergency Department. Three participants reported hiring a nurse educator to implement the protocol. Ninety-five percent of participants measure lactate as part of patient screening. Protocol therapies reported included early antibiotics (98%), early goal directed-therapy (EGDT) (98%), corticosteroids (80%), and activated protein C (73%). Contributions to success included having a protocol champion (85%) and sepsis education program (65%). Twenty-one participants had recorded patient-level data, totaling 2319 protocol patients, compared to 1719 non-protocol patients, with in-hospital mortality of 23% and 44%, respectively. Conclusions: Implementation of a sepsis management protocol incorporating evidence-based therapies can be accomplished in both academic and community hospitals, with minimal additional staffing. The presence of a protocol champion and education program is crucial to success, and may result in improved patient outcome.

Keywords: severe sepsis, septic shock, protocol implementation, survey