The Journal of Emergency Medicine
Volume 39, Issue 1 , Pages 44-48 , July 2010

Comparison of Toxicity of Acute Overdoses with Citalopram and Escitalopram

  • Bryan D. Hayes, PHARMD

      Affiliations

    • Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, Maryland
    • Corresponding Author InformationReprint Address: Bryan D. Hayes, pharmd, Maryland Poison Center, University of Maryland School of Pharmacy, 220 Arch Street, Baltimore, MD 21230
    • ,
  • Wendy Klein-Schwartz, PHARMD, MPH

      Affiliations

    • Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, Maryland
    • ,
  • Richard F. Clark, MD

      Affiliations

    • California Poison Control System – San Diego Division, University of California, San Diego, San Diego, California
    • ,
  • Allison A. Muller, PHARMD

      Affiliations

    • The Poison Control Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    • ,
  • Jane E. Miloradovich, RPH

      Affiliations

    • The Poison Control Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Received 10 April 2008 ,Revised 22 May 2008 ,Accepted 21 June 2008.

References 

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  2. Whyte IM, Dawson AH, Buckley NA. Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants. QJM. 2003;96:369–374
  3. Isbister GK, Bowe SJ, Dawson A, et al. Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose. J Toxicol Clin Toxicol. 2004;42:277–285
  4. Grundemar L, Wohlfart B, Lagerstedt C, Bengtsson F, Eklundh G. Symptoms and signs of severe citalopram overdose. Lancet. 1997;349:1602
  5. Ho R, Norman RF, van Veen MM, Anderson IB. A 3-year review of citalopram and escitalopram ingestions [abstract]. J Toxicol Clin Toxicol. 2004;42:746
  6. Personne M, Persson H, Sjoberg G. Citalopram toxicity. Lancet. 1997;350:518–519
  7. Kelly CA, Dhaun N, Laing WJ, et al. Comparative toxicity of citalopram and the newer antidepressants after overdose. J Toxicol Clin Toxicol. 2004;42:67–71
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  12. Engebretsen KM, Harris CR, Wood JE. Cardiotoxicity and late onset seizures with citalopram overdose. J Emerg Med. 2003;25:163–166
  13. Food and Drug Administration. Lexapro official labeling. www.fda.gov/cder/foi/label/2003/21323se1-003,se8-007,21365se8-001,se1-004_lexapro_lbl.pdfAccessed March 17, 2008
  14. Food and Drug Administration. Celexa official labeling. www.fda.gov/cder/foi/label/1998/20822lbl.pdfAccessed March 17, 2008
  15. Agrawal YK, Bhatt HG, Raval HG, et al. Chirality—a new era of therapeutics. Mini Rev Med Chem. 2007;7:451–460
  16. Hytell J, Bogeso KP, Perregaard J, Sanchez C. The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer. J Neural Transm. 1992;88:157–160
  17. Lane RM, Baker GB. Chirality and drug used in psychiatry: nice to know or need to know?. Cell Mol Neurobiol. 1999;19:355–372
  18. Hoffman RS. Understanding the limitations of retrospective analyses of poison center data. Clin Toxicol. 2007;45:943–945

PII: S0736-4679(08)00667-7

doi: 10.1016/j.jemermed.2008.06.030

The Journal of Emergency Medicine
Volume 39, Issue 1 , Pages 44-48 , July 2010

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