The Journal of Emergency Medicine
Volume 37, Issue 4 , Pages 376-382 , November 2009

Early Norepinephrine Infusion Delays Cardiac Arrest After Hemorrhagic Shock in Rats

  • Jae Hyuk Lee, MD

      Affiliations

    • Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Kyuseok Kim, MD, PHD

      Affiliations

    • Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, Kyung-gi do, Korea
    • Corresponding Author InformationReprint Address: Kyuseok Kim, md, phd, Department of Emergency Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Kyung-gi do, 463-707, Republic of Korea
    • ,
  • You Hwan Jo, MD

      Affiliations

    • Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, Kyung-gi do, Korea
    • ,
  • Kyung Su Kim, MD

      Affiliations

    • Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Christopher C. Lee, MD

      Affiliations

    • Department of Emergency Medicine, Center for International Emergency Medicine, Stony Brook University Medical Center, School of Medicine, Stony Brook, New York
    • ,
  • Woon Yong Kwon, MD

      Affiliations

    • Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Joong Eui Rhee, MD, PHD

      Affiliations

    • Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, Kyung-gi do, Korea
    • ,
  • Gil Joon Suh, MD, PHD

      Affiliations

    • Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea
    • ,
  • Adam J. Singer, MD

      Affiliations

    • Department of Emergency Medicine, Center for International Emergency Medicine, Stony Brook University Medical Center, School of Medicine, Stony Brook, New York

Received 16 February 2008 ,Revised 16 May 2008 ,Accepted 9 July 2008.

References 

  1. Kauvar DS, Wade CE. The epidemiology and modern management of traumatic hemorrhage: US and international perspectives. Crit Care. 2005;9(Suppl 5):S1–S9
  2. American College of Surgeons, Committee on Trauma. Advanced trauma life support for doctors (student course manual). Chicago, IL: American College of Surgeons; 2004;
  3. Moon PF, Hollyfield-Gilbert MA, Myers TL, et al. Effects of isotonic crystalloid resuscitation on fluid compartments in hemorrhaged rats. Shock. 1994;2:355–361
  4. Cotton BA, Guy JS, Morris JA, et al. The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies. Shock. 2006;26:115–121
  5. Issekutz B, Allen M. Effect of catecholamines and methyl-prednisolone on carbohydrate metabolism of dogs. Metabolism. 1972;21:48–59
  6. Liddel MJ, Daniel AM, Maclean LD, et al. The role of stress hormones in the catabolic metabolism of shock. Surg Gynecol Obstet. 1979;149:822–830
  7. Sjostrom L, Schutz Y, Gudinchet F, et al. Epinephrine sensitivity with respect to metabolic rate and other variables in women. Am J Physiol. 1983;245:E431–E442
  8. Abdul-Rasool IH, Chamberlain JH, Swan PC, et al. Cardiorespiratory and metabolic effects of dopamine and dobutamine infusions in dogs. Crit Care Med. 1987;15:1044–1050
  9. Revelly JP, Gardaz JP, Nussberger J, et al. Effect of epinephrine on oxygen consumption and delivery during progressive hemorrhage. Crit Care Med. 1995;23:1272–1278
  10. Nordin A, Makisalo H, Hockerstedt K. Dopamine infusion during resuscitation of experimental hemorrhagic shock. Crit Care Med. 1994;22:151–156
  11. Di Giantomasso , May CN, Bellomo R. Norepinephrine and vital organ blood flow. Intensive Care Med. 2002;28:1804–1809
  12. American Heart Association. 2005 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care (Part 10.7. cardiac arrest associated with trauma). Circulation. 2005;112:IV146–IV149
  13. Stern SA. Low-volume fluid resuscitation for presumed hemorrhagic shock: helpful or harmful. Curr Opin Crit Care. 2001;7:422–430
  14. Daull P, Blouin A, Cayer J, et al. Profiling biochemical and hemodynamic markers using chronically instrumented, conscious and unrestrained rats undergoing severe, acute controlled hemorrhagic hypovolemic shock as an integrated in-vivo model system to assess new blood substitutes. Vascul Pharmacol. 2005;43:289–301
  15. Burris D, Rhee P, Kaufmann C, et al. Controlled resuscitation for uncontrolled hemorrhagic shock. J Trauma. 1999;46:216–223
  16. Kowalenko T, Stern S, Dronen S, et al. Improved outcome with hypotensive resuscitation of uncontrolled hemorrhagic shock. J Trauma. 1992;33:349–353
  17. Soreide E, Grande CM. Prehospital trauma care. New York, NY: Marcel Dekker; 2001;
  18. Raedler C, Voelckel WG, Wenzel V, et al. Treatment of uncontrolled hemorrhagic shock after liver trauma: fatal effects of fluid resuscitation versus improved outcome after vasopressin. Anesth Analg. 2004;98:1759–1766
  19. Stadlbauer KH, Wagner-Berger HG, Krismer AC, et al. Vasopressin improves survival in a porcine model of abdominal vascular injury. Crit Care. 2007;11:R81
  20. Meybohm P, Cavus E, Bein B, et al. Small volume resuscitation: a randomized controlled trial with either norepinephrine or vasopressin during severe hemorrhage. J Trauma. 2007;62:640–646
  21. Horton JW. Hemorrhagic shock depresses myocardial contractile function in the guinea pig. Circ Shock. 1989;28:23–35
  22. Valverde A, Giquere S, Sanchez LC, et al. Effects of dobutamine, norepinephrine, and vasopressin on cardiovascular function in anesthetized neonatal foals with induced hypotension. Am J Vet Res. 2006;67:1730–1737
  23. Ouattara A, Landi M, Le Manach Y, et al. Comparative cardiac effects of terlipressin, vasopressin, and norepinephrine on an isolated perfused rabbit heart. Anesthesiology. 2005;102:85–92
  24. Meybohm P, Renner J, Boening A, et al. Impact of norepinephrine and fluid on cerebral oxygenation in experimental hemorrhagic shock. Pediatr Res. 2007;62:440–444
  25. Poloujadoff MP, Borron SW, Amathieu R, et al. Improved survival after resuscitation with norepinephrine in a murine model of uncontrolled hemorrhagic shock. Anesthesiology. 2007;107:591–596
  26. Su EN, Yu DY, Alder VA, et al. Effects of extracellular pH on agonist-induced vascular tone of the cat ophthalmociliary artery. Invest Ophthalmol Vis Sci. 1994;35:998–1007
  27. Yartsev VN, Karachentseva OV, Dvoretsky DP. Effect of pH changes on reactivity of rat mesenteric artery segments at different magnitude of stretch. Acta Physiol Scand. 2002;174:1–7
  28. Hoffman BB. Adrenoreceptor-activating and other sympathomimetic drugs. In:  Katzung BG editors. Basic and clinical pharmacology. 6th edn.. Norwalk, CT: Appleton & Lange; 1995;
  29. Nouira S, Elatrous S, Dimassi S, et al. Effects of norepinephrine on static and dynamic preload indicators in experimental hemorrhagic shock. Crit Care Med. 2005;33:2339–2343

PII: S0736-4679(08)00674-4

doi: 10.1016/j.jemermed.2008.07.004

The Journal of Emergency Medicine
Volume 37, Issue 4 , Pages 376-382 , November 2009

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