The Journal of Emergency Medicine
Volume 38, Issue 4 , Pages 467-476 , May 2010

Cyanide Poisoning and Cardiac Disorders: 161 Cases

  • Jean-Luc Fortin, MD

      Affiliations

    • Department of Emergency and Critical Care Medicine, Jean Minjoz University Hospital, Besançon, France
    • ,
  • Thibault Desmettre, MD, PhD

      Affiliations

    • Department of Emergency and Critical Care Medicine, Jean Minjoz University Hospital, Besançon, France
    • ,
  • Cyril Manzon, MD

      Affiliations

    • Department of Emergency and Critical Care Medicine, Jean Minjoz University Hospital, Besançon, France
    • ,
  • Virginie Judic-Peureux, MD

      Affiliations

    • Department of Emergency and Critical Care Medicine, Jean Minjoz University Hospital, Besançon, France
    • ,
  • Caroline Peugeot-Mortier, MD

      Affiliations

    • Department of Emergency and Critical Care Medicine, Jean Minjoz University Hospital, Besançon, France
    • ,
  • Jean-Pascal Giocanti, MD

      Affiliations

    • Department of Emergency and Critical Care Medicine, Jean Minjoz University Hospital, Besançon, France
    • ,
  • Mohamed Hachelaf, MD

      Affiliations

    • Department of Emergency and Critical Care Medicine, Jean Minjoz University Hospital, Besançon, France
    • ,
  • Marie Grangeon, MD

      Affiliations

    • Department of Emergency and Critical Care Medicine, Jean Minjoz University Hospital, Besançon, France
    • ,
  • Ulrike Hostalek, MD

      Affiliations

    • Merck KGaA, Darmstadt, Germany
    • Corresponding Author InformationReprint Address: Ulrike Hostalek, Merck KGaA, Frankfurterstr. 250, Darmstadt D-64293, Germany
    • ,
  • Julien Crouzet, MD

      Affiliations

    • Department of Emergency and Critical Care Medicine, Jean Minjoz University Hospital, Besançon, France
    • ,
  • Gilles Capellier, MD, PhD

      Affiliations

    • Department of Emergency and Critical Care Medicine, Jean Minjoz University Hospital, Besançon, France

Received 24 June 2009 ,Revised 10 September 2009 ,Accepted 27 September 2009.

References 

  1. Alarie Y. Toxicity of fire smoke. Crit Rev Toxicol. 2002;32:259–289
  2. Dehon B, Lhermitte M. Cyanides and anions. In:  Kintz P editors. Toxicologie and Pharmacologie Médico-Légales. Paris: Elsevier; 1998;p. 147–155
  3. O'Flaherty EJ, Thomas WC. The cardiotoxicity of hydrogen cyanide as a component of polymer pyrolysis smokes. Toxicol Appl Pharmacol. 1982;63:373–381
  4. Malis CD, Bonventre JV. Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria (A model for post-ischemic and toxic mitochondrial damage). J Biol Chem. 1986;261:4201–4208
  5. Franchini KG, Krieger EM. Cardiovascular responses of conscious rats to carotid body chemoreceptor stimulation by intravenous KCN. J Auton Nerv Syst. 1993;42:63–69
  6. Allen DG, Eisner DA, Pirolo JS, Smith GL. The relationship between intracellular calcium and contraction-overloaded ferret papillary muscles. J Physiol. 1985;364:169–182
  7. US Department of Health and Human Services. Toxicological profile for cyanide. July 2006;http://www.atsdr.cdc.gov/toxprofiles/tp8.html#bookmark09Accessed December 2008
  8. Tuovinen H, Blomquist P. Modelling of hydrogen cyanide formation in room fires. Borås, Sweden: Swedish National Testing and Research Institute; 2003;
  9. Hertzberg T, Blomquist P, Dalene M, Skarping G. Particles and isocyanate from fire. Borås, Sweden: Swedish National Testing and Research Institute; 2003;
  10. Ballantyne B. Toxicology of cyanides. In:  Ballantyne B,  Marrs TC editor. Clinical and experimental toxicology of cyanides. Bristol, UK: Wright Publishers; 1987;p. 41–46
  11. Megarbane B, Delahaye A, Goldgran-Toledano D, Baud FJ. Antidotal treatment of cyanide poisoning. J Chin Med Assoc. 2003;66:193–203
  12. Fortin JL, Ruttimann M, Domanski L, et al. Use of hydroxocobalamin. Fire Rescue International Med Congress, Las Vegas, April 15–18, 2004.
  13. Fortin JL, Giocanti JP, Ruttimann M, Kowalski JJ. Prehospital administration of hydroxocobalamin for smoke inhalation associated cyanide poisoning: 8 years of experience in the Paris Fire Brigade. Clin Toxicol (Phila). 2006;44(Suppl 1):37–44
  14. Fortin JL, Ruttimann M, Domanski L, Kowalski JJ. Hydroxocobalamin treatment for smoke inhalation associated cyanide poisoning (Meeting the needs of fire victims). JEMS. 2004;29(Suppl):18–21
  15. Baud F, Barriot P, Toffis V, et al. Elevated blood cyanide concentrations in victims of smoke inhalation. N Engl J Med. 1991;325:1761–1766
  16. Renard C, Fortin JL, Baud F. Terrorisme chimique et cyanides. In:  de Revel MC,  Gourmelon MCS,  Vidal PC,  Renaudeau PCS editor. Menace terroriste: Approche Médicale [French]. Montrouge, France: John Libbey Eurotext; 2005;p. 353–359
  17. Grangeon M. Les intoxications aux cyanures, prise en charge et traitement [French]. Besançon, France: Université de Franche-Comté, Faculté de médecine et de pharmacie de Besançon. Thèse, Année 2008 – n°08–22.

PII: S0736-4679(09)00894-4

doi: 10.1016/j.jemermed.2009.09.028

The Journal of Emergency Medicine
Volume 38, Issue 4 , Pages 467-476 , May 2010

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