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October 2013Volume 45, Issue 4, Pages 544–546
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A Case of Cannabinoid Hyperemesis Syndrome Caused by Synthetic Cannabinoids

Christopher Y. Hopkins
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Christopher Y. Hopkins
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Correspondence

  • Reprint Address: Christopher Y. Hopkins, md, Department of Emergency Medicine, University of Florida - Jacksonville Health Science Center, 655 W. 8th Street, Jacksonville, FL 32209
, MD'Correspondence information about the author MD Christopher Y. Hopkins
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Christopher Y. Hopkins
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Correspondence

  • Reprint Address: Christopher Y. Hopkins, md, Department of Emergency Medicine, University of Florida - Jacksonville Health Science Center, 655 W. 8th Street, Jacksonville, FL 32209
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Brandi L. Gilchrist
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Brandi L. Gilchrist
, MD
Department of Emergency Medicine, University of Florida - Jacksonville Health Science Center, Jacksonville, Florida
A Case of Cannabinoid Hyperemesis Syndrome Caused by Synthetic Cannabinoids
DOI: https://doi.org/10.1016/j.jemermed.2012.11.034

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Abstract

Background

Cannabinoid hyperemesis syndrome (CHS) was initially described in 2004 and remains an under-recognized clinical entity that occurs in chronic heavy marijuana smokers.

Case Report

We describe the first report of CHS in an abuser of synthetic cannabinoids. CHS is thought to be caused by over-stimulation of the cannabinoid 1 receptor. The synthetic cannabinoids found in K2, Spice, and other commonly abused designer cannabinoids, including those used by our patient (JWH-018, JWH-073, JWH-122, AM-2201, and AM-694), are potent agonists of the cannabinoid 1 receptor.

Conclusion

Our report suggests that frequent habitual smoking of synthetic cannabinoids can cause cannabinoid hyperemesis syndrome.

Keywords:

cannabinoid hyperemesis syndrome, Spice, K2, synthetic cannabinoid, JWH-073

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© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
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October 2013Volume 45, Issue 4, Pages 544–546