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Gastrointestinal obstruction associated with multiple-dose activated charcoal

DOI:https://doi.org/10.1016/0736-4679(86)90219-2
Gastrointestinal obstruction associated with multiple-dose activated charcoal
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      Abstract

      The development of a gastrointestinal obstruction associated with multiple doses of activated charcoal is described. A carbamazepine-intoxicated patient received 240 g of activated charcoal and a total of 600 mL magnesium citrate with the development of an ileus and a small-bowel obstruction. The patient also had episodes of emesis associated with charcoal administration. This case suggests that the use of multiple doses of activated charcoal may be associated with gastrointestinal obstruction, a previously unreported adverse effect. Further evaluation of the incidence of adverse effects associated with activated charcoal is needed to determine optimal therapeutic regimens.

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      References

        • Goldberg M.J.
        • Berlinger W.G.
        Treatment of phenobarbital overdose with activated charcoal.
        JAMA. 1982; 247: 2400-2401
        • Gal P.
        • Miller A.
        • McCue J.D.
        Oral activated charcoal to enhance theophylline elimination in an acute overdose.
        JAMA. 1984; 251: 3130-3131
        • Radomski L.
        • Park G.D.
        • Goldberg M.J.
        • Spector R.
        • Johnson G.F.
        • Quee C.K.
        Model for theophylline overdose treatment with oral activated charcoal.
        Clin Pharmacol Ther. 1984; 35: 402-408
        • Pond S.M.
        • Olson K.R.
        • Osterloh J.D.
        • et al.
        Randomized study of the treatment of phenobarbital overdose with repeated dose of activated charcoal.
        JAMA. 1984; 251: 3104-3108
        • Neuvonen P.J.
        • Elonen E.
        Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine and phenylbutazene in man.
        Eur J Clin Pharmacol. 1980; 17: 51-57
        • Yatzidis H.
        • Oreopoulous H.
        Early clinical trials with sorbents.
        Kidney Int. 1976; 10: S215-5217
        • Pollack M.M.
        • Dunbar B.S.
        • Holbrook P.R.
        • et al.
        Aspiration of activated charcoal and gastric contents.
        Ann Emerg Med. 1981; 10: 528-529
        • Curtis R.A.
        • Barone J.
        • Giacona N.
        Efficacy of ipecac and activated charcoal/cathartic-prevention of salicylate absorption in a simulated overdose.
        Arch Intern Med. 1984; 114: 48-52
        • Denning D.W.
        • Matheson L.
        • Bryson S.M.
        • et al.
        Death due to carbamazepine self-poisoning: remedies reviewed.
        Human Toxicol. 1985; 4: 225-260
        • Laffey S.H.
        • Guzzardi L.J.
        Phenytoin and other anticonvulsants.
        in: Haddad L.M. Winchester J.F. Clinical Management of Poisoning and Drug Overdose. WB Saunders, Philadelphia1983: 557-562
        • Pond S.M.
        Role of repeated oral doses of activated charcoal in clinical toxicology.
        Med Toxicol. 1986; 1: 3-11
        • Harsch H.H.
        Aspiration of activated charcoal.
        N Eng J Med. 1986; 314 (letter): 318
        • du Souich P.
        • Caille G.
        • Larochelle P.
        Enhancement of nadolol elimination by activated charcoal and antibiotics.
        Clin Pharmacol Ther. 1983; 33: 585-590
        • Krenzelok E.P.
        Gastrointestinal transit times of cathartics used with activated charcoal.
        Clin Pharm. 1985; 4: 446-448
        • Swartz C.M.
        • Sherman A.
        The treatment of tricyclic antidepressant overdose with repeated charcoal.
        J Clin Psychopharmacol. 1984; 4: 336-340
        • Justiniani F.R.
        • Hippalgaonkar R.
        • Martinez L.O.
        Charcoal-containing empyema complicating treatment for overdose.
        Chest. 1985; 87: 404-405
        • Pynnonen S.
        Pharmacokinetics of carbamazepine man: a review.
        Ther Drug Monit. 1979; 1: 409-431
        • O'Neal W.
        • Whitten K.M.
        • Baumann R.J.
        • et al.
        Lack of serious toxicity following carbamazepine overdose.
        Clin Pharm. 1984; 3: 545-547

      Article info

      Publication history

      Accepted: August 1, 1986
      Received: April 7, 1986

      Identification

      DOI: https://doi.org/10.1016/0736-4679(86)90219-2

      Copyright

      © 1986 Published by Elsevier Inc.

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