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Fatal nicotine ingestion

DOI:https://doi.org/10.1016/0736-4679(91)90318-A
Fatal nicotine ingestion
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      Abstract

      Nicotine is one of the most readily available and commonly abused drugs in modern society. However, serious or fatal overdoses of this agent are rare. We present a case of intentional fatal ingestion of nicotine alkaloid solution. This diagnosis may be elusive since nicotine is commonly qualitatively identified on urine toxicology screens, but is seldom quantified. Clinicians should be knowledgeable about the nature of this agent and its pathophysiologic presentations since recognition of the toxidrome is often necessary to make this diagnosis.

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      References

        • Lampe K.F.
        Systemic plant poisoning in children.
        Pediatrics. 1974; 54: 347-351
        • Manoguerra A.S.
        • Freeman D.
        Acute poisoning from the ingestion of Nicotiana glauca.
        J Toxicol Clin Toxicol. 1983; 19: 861-864
        • McNally W.D.
        A report of five cases of poisoning by nicotine.
        J Lab Clin Med. 1919; 5: 213-217
        • Willis H.W.
        Acute nicotine poisoning.
        J Pediatr. 1937; 10: 65-68
        • Oberst B.B.
        • McIntyre R.A.
        Acute nicotine poisoning.
        Pediatrics. 1953; 11: 338-340
        • Garcia-Estrada H.
        • Fischman C.M.
        An unusual case of nicotine poisoning.
        Clin Toxicol. 1977; 10: 391-393
        • Faulkner J.M.
        Nicotine poisoning by absorption through the skin.
        JAMA. 1933; 100: 1664-1665
        • Lockhart L.P.
        Nicotine poisoning.
        Br Med J. 1933; 1: 246-247
        • McNally W.D.
        A report of seven cases of nicotine poisoning.
        J Lab Clin Med. 1922; 8: 83-85
        • Beeman J.A.
        • Hunter W.C.
        Fatal nicotine poisoning.
        Arch Pathol. 1937; 24: 481-485
        • Saxena K.
        • Scheman A.
        Suicide plan by nicotine poisoning: a review of nicotine toxicity.
        Vet Hum Toxicol. 1985; 27: 495-497
        • Larson P.S.
        • Haag H.B.
        • Silvette H.
        Tobacco — experimental and clinical studies.
        Williams & Wilkins, Baltimore1961

      13. Tso TC. Effect of farm production practices on nicotine and total particulate matter in cigarette smoke. Bethesda, MD: National Cancer Institute Monograph No. 28 (pp. 97–111).

        • Ellenhom M.J.
        • Barceloux D.G.
        Medical toxicology.
        Elsevier, New York1988
        • Gosselin R.E.
        • Hodge H.C.
        • Smith R.P.
        • Gleason M.N.
        Clinical Toxicology of Commercial Products.
        Williams & Wilkins, Baltimore1976
        • Russell M.A.H.
        • Feyerabend C.
        • Cole P.V.
        Plasma nicotine levels after cigarette smoking and chewing nicotine gum.
        Br Med J. 1976; 1: 1043-1046
        • Polson C.J.
        • Green M.A.
        • Lee M.R.
        Clinical toxicology.
        Lippincott, Philadelphia1983
        • Smolinske S.C.
        • Spoerke D.G.
        • Wruk K.M.
        • et al.
        Pediatric nicotine overdose.
        Vet Hum Toxicol. 1985; 27: 308
        • Spoerke D.G.
        Nicotine (management/treatment protocol).
        in: Rumack B.H. Poisindex® information systems. Micromedex, Denver1990
        • Polson D.J.
        • Tattersall R.N.
        Clinical toxicology.
        Lippincott, Philadelphia1960
        • Volle R.L.
        • Koelle G.B.
        Ganglionic stimulating and blocking agents.
        in: Goodman L.S. Gilman A. The pharmacological basis of therapeutics. Macmillan, New York1975
        • Isersen K.V.
        Nicotine and caffeine.
        in: Haddad L.M. Winchester J.F. Clinical management of poisoning and drug overdose. Saunders, Philadelphia1983
        • McNabb M.E.
        • Ebert R.V.
        • McCuster K.
        Plasma nicotine levels produced by chewing nicotine gum.
        JAMA. 1982; 248: 865-868
        • Feyerabend C.
        • Higenbottam T.
        • Russell M.A.H.
        Nicotine concentrations in urine and saliva of smokers and nonsmokers.
        Br Med J. 1982; 284: 1002-1004
        • Etzel R.A.
        • Greenberg R.A.
        • Haley N.J.
        • Loda F.A.
        Urine cotinine excretion in neonates exposed to tobacco smoke products in utero.
        J Pediatr. 1985; 107: 146-148
        • Woodward A.
        • Miles H.
        • Grgurinovich N.
        Cotinine in urine of smokers' infants.
        Lancet. 1984; : 935
        • Andresen B.D.
        • Ng K.G.
        • Iams J.D.
        • Bianchine J.R.
        Cotinine in amniotic fluids from passive smokers.
        Lancet. 1982; : 791-792
        • Smith N.
        • Austen J.
        • Rolles C.J.
        Tertiary smoking by the fetus.
        Lancet. 1982; : 1252
        • Lefcoe N.M.
        • Ashley M.J.
        • Pederson L.L.
        • Keays J.J.
        The health risks of passive smoking.
        Chest. 1983; 84: 90-95
        • Fielding J.E.
        Smoking: health effects and control.
        N Engl J Med. 1985; 313: 491-498
        • Stock S.L.
        Passive smoking and nicotine.
        Lancet. 1981; : 1044
        • Bergman A.B.
        • Weisner L.A.
        Relationship of passive cigarette smoking to sudden infant death syndome.
        Pediatrics. 1976; 58: 665-668
        • Locket S.
        Clinical toxicology.
        Klimpton, London1957
        • Franke F.E.
        • Thomas J.E.
        The treatment of acute nicotine poisoning.
        JAMA. 1936; 106: 507-512

      Article info

      Publication history

      Accepted: August 29, 1990
      Received in revised form: August 9, 1990
      Received: April 6, 1990

      Identification

      DOI: https://doi.org/10.1016/0736-4679(91)90318-A

      Copyright

      © 1991 Published by Elsevier Inc.

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