Abstract
Several studies and reports suggest an increased risk of venous thromboembolism (VTE)
in patients treated with conventional antipsychotic drugs, as well as with clozapine.
We report the case of a 25-year-old man with early-onset schizo-affective disorder,
with no identified risk factor for thromboembolism, who developed pulmonary embolism
on three occasions, once shortly after initiating treatment with olanzapine and twice
with risperidone. This case indicates that VTE can be associated with the use of olanzapine
and risperidone, two atypical agents having similar properties and the same 5HT2 receptors
antagonism, possibly implicated in this adverse event. As suggested by this observation,
patients who have had one episode of VTE with antipsychotics with an affinity for
5HT2 receptors should receive neuroleptics from other classes, such as amisulpride,
which does not interact with 5HT2 receptors. They should also be closely monitored
to ensure early detection and prompt treatment of VTE.
Keywords
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Article info
Publication history
Published online: February 18, 2008
Accepted:
July 31,
2007
Received in revised form:
May 22,
2007
Received:
May 8,
2006
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
