This study used data from an international multi-center registry called RIETE that
is prospectively collecting consecutive patients presenting with symptomatic, acute
deep vein thrombosis (DVT) or pulmonary embolism (PE) confirmed by objective tests.
The authors analyzed demographic characteristics, treatment, and 3-month clinical
outcomes of patients with upper-extremity (UE) DVT and lower-extremity (LE) DVT. The
study evaluated 11,564 patients in the registry, of whom 512 (4.4%) had UE DVT. Patients
with UE DVT presented with PE less often (9.0% vs. 29%, respectively) compared to
those with LE DVT. Of the 512 patients with UE DVT, 196 patients (38%) had cancer
and 228 patients (45%) had catheter-related DVT. At 3-month follow-up, patients with
cancer-related UE DVT had increased incidence of major bleeding, recurrent venous
thromboembolism, and death when compared to non-cancer-related UE DVT. The authors
concluded that although UE DVT may not present with PE as often as LE DVT, there is
significant morbidity and mortality associated with UE DVT, particularly in patients
with cancer-related UE DVT.
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© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
