Religious fasting is associated with headache. This has been documented as “First of Ramadan Headache” and “Yom Kippur Headache.” Rofecoxib (Vioxx®; Merck) and etoricoxib, both Cox-2 inhibitors with 17- and 22-h half-lives, respectively, have been shown to be effective in preventing fasting headache when taken just before the 25-h Yom Kippur fast. Rofecoxib is no longer available. We hypothesized that etoricoxib would also be effective in preventing fasting headache during the dawn-to-dusk Ramadan fast.
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© 2011 Published by Elsevier Inc.