Injury from major trauma remains a significant source of morbidity and mortality worldwide. Lifesaving therapies such as early blood transfusion after traumatic injury have enabled survival or improved morbidity. As a result of the increased use of early blood transfusion after traumatic injury, the incidence of adverse effects resulting from such early transfusion has also increased, including an increase in the incidence of post-transfusion acute lung injury (ALI). Prior studies demonstrated an overall risk for development of ALI after transfusion in the first 24–48 h of hospitalization, yet did not assess if the association varied with exact time of transfusion after traumatic injury. The current study aimed to better delineate this relationship.
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© 2013 Published by Elsevier Inc.