Advertisement
Evidence-Based Medicine| Volume 45, ISSUE 1, P117-127, July 2013

Is Emergency Department Cardioversion of Recent-onset Atrial Fibrillation Safe and Effective?

      Abstract

      Background

      Atrial fibrillation (AF) is a very common dysrhythmia presenting to Emergency Departments (EDs). Controversy exists regarding the optimal clinical therapy for these patients, which typically focuses on rhythm rate-control and admission or cardioversion and discharge home.

      Clinical Question

      Is ED cardioversion of recent-onset atrial fibrillation safe, effective, and does it result in positive meaningful patient outcomes?

      Evidence Review

      Five observation studies with nearly 1600 ED patients with atrial fibrillation treated with either rate-control or cardioversion were reviewed and results compiled.

      Results

      Overall, ED cardioversion for recent-onset AF seems safe and effective, with success rates ranging from 85.5% to 97% in these studies. Although further research should seek to identify patients at low risk for thromboembolic complication, more rigorously assess patient satisfaction, and show cost savings, emergency physicians should feel comfortable using this approach in select patients.

      Conclusion

      ED cardioversion for recent-onset AF seems safe and effective.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Emergency Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Miyasaka Y.
        • Barnes M.E.
        • Gersh B.J.
        • et al.
        Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence.
        Circulation. 2006; 114: 119-125
        • McDonald A.J.
        • Pelletier A.J.
        • Ellinor P.T.
        • Camargo Jr., C.A.
        Increasing US emergency department visit rates and subsequent hospital admissions for atrial fibrillation from 1993 to 2004.
        Ann Emerg Med. 2008; 51: 58-65
        • Coyne K.S.
        • Paramore C.
        • Grandy S.
        • Mercader M.
        • Reynolds M.
        • Zimetbaum P.
        Assessing the direct costs of treating nonvalvular atrial fibrillation in the United States.
        Value Health. 2006; 9: 348-356
        • Arco C.
        • Martin A.
        • Laguna P.
        • Gargantilla P.
        Analysis of current management of atrial fibrillation in the acute setting: GEFAUR-1 Study.
        Ann Emerg Med. 2005; 46: 424-430
        • Van Gelder I.C.
        • Hagens V.E.
        • Bosker H.A.
        • et al.
        A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation.
        N Engl J Med. 2002; 347: 1834-1840
        • The Atrial Fibrillation Follow-up Investigation of Rhythm management (AFFIRM) Investigators
        A comparison of rate control and rhythm control in patients with atrial fibrillation.
        N Engl J Med. 2002; 347: 1825-1833
        • Hohnsloser S.K.
        • Kuck K.H.
        • Lilienthal J.
        Rhythm or rate control in AF: pharmacological intervention in atrial fibrillation (PIAF): a randomised trial.
        Lancet. 2000; 356: 1789-1794
        • Marshall D.A.
        • Levy A.R.
        • Vidaillet H.
        • et al.
        Cost-effectiveness of rhythm versus rate control in atrial fibrillation.
        Ann Intern Med. 2004; 141: 653-661
        • Hagens V.E.
        • Vermeulen K.M.
        • TenVergert E.M.
        • et al.
        Rate control is more cost-effective than rhythm control for patients with persistent atrial fibrillation—results from the RAte Control versus Electrical cardioversion (RACE) study.
        Eur Heart J. 2004; 25: 1542-1549
        • Stiell I.G.
        • Birnie D.
        Managing recent-onset atrial fibrillation in the emergency department.
        Ann Emerg Med. 2011; 57: 31-32
        • Raghavan A.V.
        • Decker W.W.
        • Meloy T.D.
        Management of atrial fibrillation in the emergency department.
        Emerg Med Clin North Am. 2005; 23: 1127-1139
        • Lévy S.
        Epidemiology and classification of atrial fibrillation.
        J Cardiovasc Electrophysiol. 1998; 9: S78-S82
      1. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials.
        Arch Intern Med. 1994; 154: 1449-1457
        • Bjerkelund C.J.
        • Orning O.M.
        The efficacy of anticoagulant therapy in preventing embolism related to D.C. electrical conversion of atrial fibrillation.
        Am J Cardiol. 1969; 23: 208-216
        • Arnold A.Z.
        • Mick M.J.
        • Mazurek R.P.
        • et al.
        Role of prophylactic anticoagulation for direct current cardioversion in patients with atrial fibrillation or atrial flutter.
        J Am Coll Cardiol. 1992; 19: 851-855
        • Cordina J.
        • Mead G.E.
        Pharmacological cardioversion for atrial fibrillation and flutter.
        Cochrane Database Syst Rev. 2005; 2: CD003713
        • Mead G.E.
        • Elder A.
        • Flapan A.D.
        • Cordina J.
        Electrical cardioversion for atrial fibrillation and flutter.
        Cochrane Database Syst Rev. 2005; 3: CD002903
        • Weigner M.J.
        • Caulfield T.A.
        • Danias P.G.
        • Silverman D.I.
        • Manning W.J.
        Risk for clinical thromboembolism associated with cardioversion to sinus rhythm in patients with atrial fibrillation lasting less than 48 hours.
        Ann Intern Med. 1997; 126: 615-620
        • Page R.L.
        • Wilkinson W.E.
        • Clair W.K.
        • McCarthy E.A.
        • Pritchett E.
        Asymptomatic arrhythmias in patients with symptomatic paroxysmal atrial fibrillation and paroxysmal supraventricular tachycardia.
        Circulation. 1994; 89: 224-227
        • Strickberger S.A.
        • Ip J.
        • Saksena S.
        • Curry K.
        • Bahnson T.D.
        • Ziegler P.D.
        Relationship between atrial tachyarrhythmias and symptoms.
        Heart Rhythm. 2005; 2: 125-131
        • Tayal A.H.
        • Tian M.
        • Kelly K.M.
        • et al.
        Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke.
        Neurology. 2008; 71: 1696-1701
        • Xavier Scheuermeyer F.
        • Grafstein E.
        • Stenstrom R.
        • Innes G.
        • Poureslami I.
        • Sighary M.
        Thirty-day outcomes of emergency department patients undergoing electrical cardioversion for atrial fibrillation or flutter.
        Acad Emerg Med. 2010; 17: 408-415
        • Burton J.H.
        • Vinson D.R.
        • Drummond K.
        • Strout T.D.
        • Thode H.C.
        • McInturff J.J.
        Electrical cardioversion of emergency department patients with atrial fibrillation.
        Ann Emerg Med. 2004; 44: 20-30
        • Vinson D.R.
        • Hoehn T.
        • Graber D.J.
        • Williams T.M.
        Managing emergency department patients with recent-onset atrial fibrillation.
        J Emerg Med. 2012; 42: 139-148
        • Stiell I.G.
        • Clement C.M.
        • Perry J.J.
        • et al.
        Association of the Ottawa Aggressive Protocol with rapid discharge of emergency department patients with recent-onset atrial fibrillation or flutter.
        CJEM. 2010; 12: 181-191
        • Jacoby J.L.
        • Cesta M.
        • Heller M.B.
        • Salen P.
        • Reed J.
        Synchronized emergency department cardioversion of atrial dysrhythmias saves time, money, and resources.
        J Emerg Med. 2005; 28: 27-30
        • Stiell I.G.
        • Macle L.
        CCS Atrial Fibrillation Guidelines Committee. Canadian Cardiovascular Society atrial fibrillation guidelines 2010: Management of recent-onset atrial fibrillation and flutter in the emergency department.
        Can J Cardiol. 2011; 27: 38-46
        • Gage B.F.
        • Waterman A.D.
        • Shannon W.
        • Boechler M.
        • Rich M.W.
        • Radford M.J.
        Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation.
        JAMA. 2001; 285: 2864-2870
        • Gage B.F.
        • van Walraven C.
        • Pearce L.
        • et al.
        Selecting patients with atrial fibrillation for anticoagulation: stroke risk stratification in patients taking aspirin.
        Circulation. 2004; 110: 2287-2292
        • Berger M.
        • Schweitzer P.
        Timing of thromboembolic events after electrical cardioversion of atrial fibrillation or flutter: a retrospective analysis.
        Am J Cardiol. 1998; 82 (A8): 1545-1547
        • Sullivan E.
        • Braithwaite S.
        • Dietz K.
        • et al.
        Health services utilization and medical costs among Medicare atrial fibrillation patients.
        Avalere Health LLC, Washington, DC2010
      2. Lenth RV. Java applets for power and sample size [computer software; 2006–9]. Available at: http://www.stat.uiowa.edu/∼rlenth/Power. Accessed May 23, 2012

        • Halpern S.D.
        • Karlawish J.H.T.
        • Berlin J.A.
        The continuing unethical conduct of underpowered clinical trials.
        JAMA. 2002; 288: 358-362
        • Moher D.
        • Dulberg C.S.
        • Wells G.A.
        Statistical power, sample size, and their reporting in randomized controlled trials.
        JAMA. 1994; 272: 122-124
        • Jones S.R.
        • Carley S.
        • Harrison M.
        An introduction to power and sample size estimation.
        Emerg Med J. 2003; 20: 453-458
        • Sun B.C.
        • Adams J.G.
        • Burstin H.R.
        Validating a model of patient satisfaction with emergency care.
        Ann Emerg Med. 2001; 38: 527-532
        • Granado de la Orden S.
        • García A.C.
        • Rodríguez Gijón L.F.
        • Rodríguez Rieiro C.
        • Sanchidrian de Blas C.
        • Rodríguez Pérez P.
        Development and validation of a questionnaire to assess satisfaction with hospital emergency care.
        Emerg Med J. 2011; 28: 770-774
      3. Owens PL, Mutter R. Payers of emergency department care, 2006. HCUP Statistical Brief #77. Rockville, MD: Agency for Healthcare Research and Quality; 2009

        • Asplin B.R.
        • Rhodes K.V.
        • Levy H.
        • et al.
        Insurance status and access to urgent ambulatory care follow-up appointments.
        JAMA. 2005; 294: 1248-1254