Abstract| Volume 47, ISSUE 6, P755-756, December 2014

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Bleeding Risk of Patients With Acute Venous Thromboembolism Taking Nonsteroidal Anti-Inflammatory Drugs or Aspirin

Davidson B, Verheijen S, Lensing A, et al. JAMA Intern Med 2014;174(6):947−53.
      Anticoagulation therapy for treatment of deep vein thrombosis (DVT) or pulmonary embolism (PE) is associated with an increased bleeding risk, although it often exists alongside nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin use for treatment of chronic comorbid conditions, such as atherosclerotic vascular disease, or for general use. The increased bleeding risk as a result of using aspirin with anticoagulation in patients with atrial fibrillation, prosthetic valves, and ischemic heart disease has been well described. To the authors’ knowledge, data estimating the bleeding risk of anticoagulant use for treatment of DVT/PE with concomitant use of NSAIDs or aspirin had not been reported.
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