Very Early Administration of Progesterone for Acute Traumatic Brain Injury: Wright DW, Yeatts SD, Silbergleit R, et al. N Engl J Med 2014;371:2457−66.

Kevin Butler

doi:10.1016/j.jemermed.2015.02.030

Abstract| Volume 48, ISSUE 4, P523, April 2015

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Very Early Administration of Progesterone for Acute Traumatic Brain Injury

Wright DW, Yeatts SD, Silbergleit R, et al. N Engl J Med 2014;371:2457−66.

Kevin Butler, MD
Kevin Butler
Affiliations
Denver Health Medical Center, Denver, CO
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DOI:https://doi.org/10.1016/j.jemermed.2015.02.030

This large, prospective randomized trial investigated the efficacy of early progesterone administration in nonpenetrating, blunt traumatic brain injury (TBI). Before this study, animal research and small clinical trials suggested that early progesterone administration after TBI was associated with improved neurologic outcomes.

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DOI: https://doi.org/10.1016/j.jemermed.2015.02.030

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