Abstract
Background
While transient ischemic attack and minor stroke (TIAMS) are common conditions evaluated
in the emergency department (ED), there is controversy regarding the most effective
and efficient strategies for managing them in the ED. Some patients are discharged
after evaluation in the ED and cared for in the outpatient setting, while others remain
in an observation unit without being admitted or discharged, and others experience
prolonged and potentially costly inpatient admissions.
Objective of the Review
The goal of this clinical review was to summarize and present recommendations regarding
the disposition of TIAMS patients in the ED (e.g., admission vs. discharge).
Discussion
An estimated 250,000 to 300,000 TIA events occur each year in the United States, with
an estimated near-term risk of subsequent stroke ranging from 3.5% to 10% at 2 days,
rising to 17% by 90 days. While popular and easy to use, reliance solely on risk-stratification
tools, such as the ABCD2, should not be used to determine whether TIAMS patients can
be discharged safely. Additional vascular imaging and advanced brain imaging may improve
prediction of short-term neurologic risk. We also review various disposition strategies
(e.g., inpatient vs. outpatient/ED observation units) with regard to their association
with neurologic outcomes, such as 30-day or 90-day stroke recurrence or new stroke,
in addition to other outcomes, such as hospital length of stay and health care costs.
Conclusions
Discharge from the ED for rapid outpatient follow-up may be a safe and effective strategy
for some forms of minor stroke without disabling deficit and TIA patients after careful
evaluation and initial ED workup. Future research on such strategies has the potential
to improve neurologic and overall patient outcomes and reduce hospital costs and ED
length of stay.
Keywords
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References
- Executive summary: Heart Disease and Stroke Statistics-2016 update: a report from the American Heart Association.Circulation. 2016; 133: 447
- Forecasting the future of stroke in the united states.Stroke. 2013; 44: 2361-2375
- Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association.Circulation. 2017; 135: e146-e603
- Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists.Stroke. 2009; 40: 2276-2293
- Early risk of stroke after transient ischemic attack: a systematic review and meta-analysis.Arch Intern Med. 2007; 167: 2417-2422
- National study on emergency department visits for transient ischemic attack, 1992–2001.Acad Emerg Med. 2006; 13: 666-672
- Trends in hospitalizations and cost associated with acute ischemic stroke by age, United States 2003–2012.Am Heart Assoc. 2016; 11: 874-881
- What is a minor stroke?.Stroke. 2010; 41: 661-666
- Validation of minor stroke definitions for thrombolysis decision making.J Stroke Cerebrovasc Dis. 2013; 22: 482-490
- Scientific rationale for the inclusion and exclusion criteria for intravenous alteplase in acute ischemic stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association.Stroke. 2016; 47: 581-641
- Strokes with minor symptoms: an exploratory analysis of the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials.Stroke. 2010; 41: 2581-2586
- Outcomes in mild acute ischemic stroke treated with intravenous thrombolysis: a retrospective analysis of the Get With the Guidelines–Stroke registry.JAMA Neurol. 2015; 72: 423-431
- Systematic review of stroke thrombolysis service configuration.Expert Rev Neurother. 2009; 9: 211-233
- Primary and comprehensive stroke centers: history, value and certification criteria.J Stroke. 2013; 15: 78-89
- Incidence and short-term prognosis of transient ischemic attack in a population-based study.Stroke. 2005; 36: 720-723
- Short-term prognosis after emergency department diagnosis of TIA.JAMA. 2000; 284: 2901-2906
- Admitting acute ischemic stroke patients to a stroke care monitoring unit versus a conventional stroke unit.Stroke. 2003; 34: 101-104
- Stroke-unit care for acute stroke patients: an observational follow-up study.Lancet. 2007; 369: 299-305
- Systematic review of economic evidence on stroke rehabilitation services.Int J Technol Assess Health Care. 2005; 21: 15-21
- Hospital and demographic influences on the disposition of transient ischemic attack.Acad Emerg Med. 2008; 15: 171-176
- Managing patients with transient ischemic attack.Ann Emerg Med. 2018; 71: 409-415
- Clinical policy: critical issues in the evaluation of adult patients with suspected transient ischemic attack in the emergency department.Ann Emerg Med. 2016; 68: 354-370.e29
- A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack.Lancet. 2005; 366: 29-36
- Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack.Lancet. 2007; 369: 283-292
- Addition of brain infarction to the ABCD2 Score (ABCD2I): a collaborative analysis of unpublished data on 4574 patients.Stroke. 2010; 41: 1907-1913
- Addition of brain and carotid imaging to the ABCD(2) score to identify patients at early risk of stroke after transient ischaemic attack: a multicentre observational study.Lancet Neurol. 2010; 9: 1060-1069
- Higher ABCD2 score predicts patients most likely to have true transient ischemic attack.Stroke. 2008; 39: 3096-3098
- Stroke: The Diagnosis and Acute Management of Stroke and Transient Ischemic Attacks.National Institute for Health and Clinical Excellence, London2008
- National Stroke Association recommendations for systems of care for transient ischemic attack.Ann Neurol. 2011; 69: 872-877
- Patterns and predictors of early risk of recurrence after transient ischemic attack with respect to etiologic subtypes.Stroke. 2007; 38: 3225-3229
- One-year risk of stroke after transient ischemic attack or minor stroke.N Engl J Med. 2016; 374: 1533-1542
- Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging.Ann Neurol. 2005; 57: 848-854
- Imaging parameters and recurrent cerebrovascular events in patients with minor stroke or transient ischemic attack.JAMA Neurol. 2016; 73: 572-578
- DWI lesions and TIA etiology improve the prediction of stroke after TIA.Stroke. 2009; 40: 187-192
- Population-based study of ABCD2 score, carotid stenosis, and atrial fibrillation for early stroke prediction after transient ischemic attack: the North Dublin TIA study.Stroke. 2010; 41: 844-850
- Triaging TIA/minor stroke patients using the ABCD2 score does not predict those with significant carotid disease.Eur J Vasc Endovasc Surg. 2012; 43: 495-498
- Performance of the ABCD and ABCD2 scores in TIA patients with carotid stenosis and atrial fibrillation.Cerebrovasc Dis. 2007; 24: 231-235
- Factors associated with the decision to hospitalize patients after transient ischemic attack before publication of prediction rules.Stroke. 2008; 39: 411-413
- Validation of the ABCD3-I score to predict stroke risk after transient ischemic attack.Stroke. 2013; 44: 1244-1248
- ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack.Stroke. 2014; 45: 418-425
- Predictive value of brain and vascular imaging including intracranial vessels in transient ischaemic attack patients: external validation of the ABCD3-I score.Eur J Neurol. 2013; 20: 1088-1093
- Transient ischemic attack (TIA): the initial diagnostic and therapeutic dilemma.Am J Emerg Med. 2012; 30: 794-799
- Admission rates of ED patients with transient ischemic attack have increased since 2000.Am J Emerg Med. 2013; 31: 1349-1351
- Rates and factors associated with admission in patients presenting to the ED with TIA in the United States—2006 to 2008.Am J Emerg Med. 2013; 31: 516-519
- Is hospitalization after TIA cost-effective on the basis of treatment with tPA?.Neurology. 2005; 65: 1799-1801
- Should TIA patients be hospitalized or referred to a same-day clinic? A decision analysis.Neurology. 2011; 77: 2082-2088
- Association between hospitalization and care after transient ischemic attack or minor stroke.Neurology. 2016; 86: 1582-1589
- An analysis of transient ischemic attack practices: does hospital admission improve patient outcomes?.J Stroke Cerebrovasc Dis. 2016; 25: 2122-2125
- Improved door-to-needle times and neurologic outcomes when IV tissue plasminogen activator is administered by emergency physicians with advanced neuroscience training.Am J Emerg Med. 2015; 33: 234-237
- Indications for early aspirin use in acute ischemic stroke.Stroke. 2000; 31: 1240-1249
- Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention.Lancet Neurol. 2009; 8: 453-463
- Early outcome of carotid angioplasty and stenting with and without cerebral protection devices.Stroke. 2003; 34: 813-819
- TIA clinic: a major advance in management of transient ischemic attacks.in: Uchiyama S. Amarenco P. Minematsu K. Wong K.S.L. TIA as acute cerebrovascular syndrome. Karger Publishers, Basel, Switzerland2013: 30-40
- Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison.Lancet. 2007; 370: 1432-1442
- An emergency department diagnostic protocol for patients with transient ischemic attack: a randomized controlled trial.Ann Emerg Med. 2007; 50: 109-119
- Evaluation of transient ischemic attack in an emergency department observation unit.Neurocrit Care. 2009; 10: 204
- Risk of myocardial infarction and vascular death after transient ischemic attack and ischemic stroke.Stroke. 2005; 36: 2748-2755
- Impact of an emergency department observation unit transient ischemic attack protocol on length of stay and cost.J Stroke Cerebrovasc Dis. 2012; 21: 673-678
- Costs of an emergency department—based accelerated diagnostic protocol vs hospitalization in patients with chest pain: a randomized controlled trial.JAMA. 1997; 278: 1670-1676
- Patient satisfaction with an emergency department chest pain observation unit.Ann Emerg Med. 1997; 29: 109-115
- An emergency department-based protocol for rapidly ruling out myocardial ischemia reduces hospital time and expense: results of a randomized study (ROMIO).J Am Coll Cardiol. 1996; 28: 25-33
- Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis.Lancet Neurol. 2007; 6: 1063-1072
- National Stroke Association guidelines for the management of transient ischemic attacks.Ann Neurol. 2006; 60: 301-313
- Guidelines for the early management of adults with ischemic stroke.Circulation. 2007; 115: e478-e534
- Randomised controlled trial to evaluate early discharge scheme for patients with stroke.BMJ. 1997; 315: 1039-1044
- Effect of urgent treatment for transient ischaemic attack and minor stroke on disability and hospital costs (EXPRESS study): a prospective population-based sequential comparison.Lancet Neurol. 2009; 8: 235-243
- Emergency department crowding and time to care in patients with acute stroke.Stroke. 2011; 42: 1074-1080
- The effect of emergency department crowding on patient satisfaction for admitted patients.Acad Emerg Med. 2008; 15: 825-831
- Perceived clinician-patient communication in the emergency department and subsequent post-traumatic stress symptoms in patients evaluated for acute coronary syndrome.Emerg Med J. 2016; 33: 626-631
- Patient treatment in ED hallways and patient perception of clinician-patient communication.Am J Emerg Med. 2016; 34: 1163-1164
- An enduring somatic threat model of posttraumatic stress disorder due to acute life-threatening medical events.Soc Personal Psychol Compass. 2014; 8: 118-134
- Treatment rates for PTSD and depression in recently hospitalized cardiac patients.J Psychosom Res. 2016; 86: 60-62
- Patient perceptions of stress during evaluation for acute coronary syndrome in the emergency department.Am J Emerg Med. 2017; 35: 351-352
- Association of social support during emergency department evaluation for acute coronary syndrome with subsequent posttraumatic stress symptoms.J Behav Med. 2016; 39: 823-831
Article info
Publication history
Published online: January 08, 2018
Accepted:
December 1,
2017
Received in revised form:
November 5,
2017
Received:
July 22,
2017
Identification
Copyright
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