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Letters to the Editor| Volume 57, ISSUE 2, P250-253, August 2019

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Should Target Glycemic Range Be Exactly the Same for Patients With Acute Myocardial Infarction Versus Without Diabetes?

      Pronounced hyperglycemia by itself is a dangerous condition, but it is particularly dangerous when accompanied by ketoacidosis or a hyperglycemic hyperosmolar state (
      • Umpierrez G.
      • Korytkowski M.
      Diabetic emergencies - ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia.
      ). The measurement of glycemia is universally available and inexpensive. Glycemia is often measured in the emergency department (ED); in almost 20% of patients, glucose concentration in serum is evaluated, and capillary glucose measurement is required in an additional large number of patients (
      • Ginde A.A.
      • Delaney K.E.
      • Pallin D.J.
      • Camargo Jr., C.A.
      Multicenter survey of emergency physician management and referral for hyperglycemia.
      ). Another rationale for measuring glycemia in the ED is the fact that every fourth patient in the ED has diabetes mellitus (DM) (
      • Arora S.
      • Henderson S.O.
      • Long T.
      • Menchine M.
      Diagnostic accuracy of point-of-care testing for diabetic ketoacidosis at emergency-department triage: β-hydroxybutyrate versus the urine dipstick.
      ). Glycemic control (and therefore the target range) are important things to be aware of in the ED (
      • Ginde A.A.
      • Delaney K.E.
      • Pallin D.J.
      • Camargo Jr., C.A.
      Multicenter survey of emergency physician management and referral for hyperglycemia.
      ,
      • Pourmand A.
      • Mazer-Amirshahi M.
      • Caggiula A.
      • et al.
      Targeted glycemic control for adult patients with type 2 diabetes mellitus in the acute care setting.
      ,
      • Zelihic E.
      • Poneleit B.
      • Siegmund T.
      • et al.
      Hyperglycemia in emergency patients—prevalence and consequences: results of the GLUCEMERGE analysis.
      ,
      • Yan J.W.
      • Hamelin A.L.
      • Gushulak K.M.
      • et al.
      Hyperglycemia in young adults with types 1 and 2 diabetes seen in the emergency department: a health records review.
      ,
      • Crilly C.J.
      • Allen A.J.
      • Amato T.M.
      • et al.
      Evaluating the Emergency Department Observation Unit for the management of hyperglycemia in adults.
      ,
      • Munoz C.
      • Villanueva G.
      • Fogg L.
      • et al.
      Impact of a subcutaneous insulin protocol in the emergency department: Rush Emergency Department Hyperglycemia Intervention (REDHI).
      ,
      • Bernard J.B.
      • Munoz C.
      • Harper J.
      • et al.
      Treatment of inpatient hyperglycemia beginning in the emergency department: a randomized trial using insulins aspart and detemir compared with usual care.
      ,
      • Johnson-Clague M.
      • DiLeo J.
      • Katz M.D.
      • Patanwala A.E.
      Effect of full correction versus partial correction of elevated blood glucose in the emergency department on hospital length of stay.
      ,
      • Magee M.F.
      • Nassar C.M.
      • Mete M.
      • et al.
      The synergy to enable glycemic control following emergency department discharge program for adults with type 2 diabetes: step-diabetes.
      ,
      • Silverman R.A.
      • Pahk R.
      • Carbone M.
      • et al.
      The relationship of plasma glucose and HbA1c Levels among emergency department patients with no prior history of diabetes mellitus.
      ,
      • Moghissi E.S.
      • Korytkowski M.T.
      • DiNardo M.
      • et al.
      American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control.
      ,
      • Gomez-Peralta F.
      • Abreu C.
      • Andreu-Urioste L.
      • et al.
      Point-of-care capillary HbA1c measurement in the emergency department: a useful tool to detect unrecognized and uncontrolled diabetes.
      ,
      • Kuhn L.
      • Lee G.
      The need for increased vigilance in managing hyperglycaemia during acute coronary syndrome in the emergency department: an introduction to the evidence.
      ,
      • Lee J.H.
      • Kim K.
      • Jo Y.H.
      • et al.
      Feasibility of continuous glucose monitoring in critically ill emergency department patients.
      ,
      • Arora S.
      • Cheng D.
      • Wyler B.
      • Menchine M.
      Prevalence of hypokalemia in ED patients with diabetic ketoacidosis.
      ). High serum glucose concentration in the ED is a valid marker of in-hospital morbidity and mortality (
      • Pourmand A.
      • Mazer-Amirshahi M.
      • Caggiula A.
      • et al.
      Targeted glycemic control for adult patients with type 2 diabetes mellitus in the acute care setting.
      ,
      • Zelihic E.
      • Poneleit B.
      • Siegmund T.
      • et al.
      Hyperglycemia in emergency patients—prevalence and consequences: results of the GLUCEMERGE analysis.
      ). Despite the prognostic significance of hyperglycemia in the ED, its management in the ED is clearly suboptimal (
      • Zelihic E.
      • Poneleit B.
      • Siegmund T.
      • et al.
      Hyperglycemia in emergency patients—prevalence and consequences: results of the GLUCEMERGE analysis.
      ). It may be advantageous to start proper hypoglycemic treatment in the ED because it results in faster achievement of the glycemic target(s).
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