Abstract
Background
Clenbuterol is a long-acting β-adrenergic agonist that is not Food and Drug Administration–approved
for use in the United States, but may be obtained without a prescription from various
unregulated sellers. It has seen increasing use as a performance-enhancing drug for
sports. Literature on pediatric toxicity and treatment is limited.
Case Report
We report a case of a 2-year-old female presenting after an exploratory ingestion
of clenbuterol.
Why Should an Emergency Physician Be Aware of This?
Use of performance-enhancing agents is increasing and physicians should be aware of
the potential toxicity of intentional and unintentional ingestions of β-adrenergic
agonists. Patients may exhibit nausea, vomiting, tremor, tachycardia, and hypotension,
along with laboratory abnormalities, including hyperglycemia, hypophosphatemia, hypokalemia,
and hyperglycemia. Hypotension might not respond to adrenergic agents and may require
administration of β-adrenergic antagonists to maintain adequate perfusion.
Keywords
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References
- Acute clenbuterol overdose resulting in supraventricular tachycardia and atrial fibrillation.J Med Toxicol. 2007; 3: 56-60
- Pharmacokinetics of plasma and urine clenbuterol in man, rat, and rabbit.J Pharmacobiodyn. 1985; 8: 385-391
- β2 agonists as misusing drugs? assessment of both clenbuterol- and salbutamol-related European Medicines Agency (EMA) pharmacovigilance database reports.Basic Clin Pharmacol Toxicol. 2018; 123: 182-187
- Clenbuterol toxicity: a NSW Poisons Information Centre experience.Med J Aust. 2014; 200: 219-221
- A descriptive study of adverse events from clenbuterol misuse and abuse for weight loss and bodybuilding.Subst Abuse. 2013; 34: 306-312
- Unsuspected clenbuterol toxicity in a patient using intramuscular testosterone.Clin Pract Cases Emerg Med. 2017; 1: 197-200
- Detection of clenbuterol in heroin users in twelve postmortem cases at the Philadelphia medical examiner's office.J Anal Toxicol. 2008; 32: 522-528
- A case series of clenbuterol toxicity caused by adulterated heroin.J Emerg Med. 2016; 51: 259-261
- An outbreak of beta-2 adrenergic toxicity from adulterated heroin.Am J Med. 2016; 129: e125-e126
- A descriptive study of an outbreak of clenbuterol-containing heroin.Ann Emerg Med. 2008; 52: 548-553
- A novel neuromuscular syndrome associated with clenbuterol-tainted heroin.Clin Toxicol. 2010; 46: 1088-1092
- Myocardial ischemia associated with clenbuterol abuse: report of two cases.J Emerg Med. 2013; 44: 444-449
- Clenbuterol causing non–ST-segment elevation myocardial infarction in a teenage female desiring to lose weight: case and brief literature review.Am J Emerg Med. 2016; 34: 1739.e5-1739.e7
- Myocardial infarction in a 17-year-old body builder using clenbuterol.Circ J. 2005; 69: 1144-1146
- Chomping at the bit: a descriptive report of pediatric clenbuterol ingestion.J Pharm Pract. 2019; ([Epub ahead of print])
- [Clinical features and treatment of acute clenbuterol poisoning in children].Zhongguo Dang Dai Er Ke Za Zhi. 2013; 15: 886-889
Article info
Publication history
Published online: September 04, 2019
Accepted:
June 15,
2019
Received in revised form:
June 3,
2019
Received:
April 18,
2019
Footnotes
Drs. Bonney, Hatten, and Wang contributed to the writing of the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.