Abstract| Volume 57, ISSUE 4, P594-595, October 2019

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction

Neumann JT, Twerenbold R, Ojeda F, et al. The New England Journal of Medicine 2019;380:2529-40
      Chest pain is universally a leading cause of emergency department visits. Technological advancements have led to the development of high-sensitivity troponin assays. The application, interpretation, and appropriate utilization of their results is still under investigation. Furthermore, the increased sensitivity of these assays raises additional challenges such as determination of true myocardial infarction (MI) versus other causes of myocardial injury, appropriate timing of serial troponin sampling (i.e., from 1 to 6 hours), and prognostic implications of persistently elevated troponin levels. This study sought to develop a calculator capable of identifying the probability of acute MI (AMI) and 30-day outcomes, as well as provide prognostic information on patients identified as not having a myocardial infarction.
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