Abstract
Background
Patients who present emergently with focal neurological deficits concerning for acute
ischemic stroke can be extremely challenging to diagnose and treat. Unnecessary administration
of thrombolytics to potential stroke patients whose symptoms are not caused by an
acute ischemic stroke—stroke mimics—may result in patient harm, although the overall
risk of hemorrhagic complications among stroke mimics is low.
Case Report
We present a case of a stroke mimic patient with underlying psychiatric disease who
was treated with intravenous alteplase on four separate occasions in four different
emergency departments in the same city. Although he did not suffer hemorrhagic complications,
this case highlights the importance of rapid exchange of health information across
institutions to improve diagnostic quality and safety.
Why Should an Emergency Physician Be Aware of This?
Increased awareness of stroke mimics by emergency physicians may improve diagnostic
safety for a subset of high-risk patients. Establishing rapid cross-institutional
communication pathways that are integrated into provider's workflows to convey essential
patient health information has potential to improve stroke diagnostic decision-making
and thus represents an important topic for health systems research in emergency medicine.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Emergency MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Safety of intravenous thrombolysis in stroke mimics: prospective 5-year study and comprehensive meta-analysis.Stroke. 2015; 46: 1281-1287
- Effects of increasing IV tPA-treated stroke mimic rates at CT-based centers on clinical outcomes.Neurology. 2017; 89: 343-348
- Cost burden of stroke mimics and transient ischemic attack after intravenous tissue plasminogen activator treatment.J Stroke Cerebrovasc Dis. 2015; 24: 828-833
- Is the cost-effectiveness of stroke thrombolysis affected by proportion of stroke mimics?.Stroke. 2019; 50: 463-468
- Improving diagnosis in healthcare.The National Academies Press, Washington, DC2015
- Diagnostic discordance, health information exchange, and inter-hospital transfer outcomes: a population study.J Gen Intern Med. 2018; 33: 1447-1453
- Minimizing diagnostic error: the importance of follow-up and feedback.Am J Med. 2008; 121: S38-S42
- Swift or sure? The acceptable rate of neurovascular mimics among IV tPA-treated patients.Neurology. 2010; 74: 1336-1337
- Incidence and outcome of functional stroke mimics admitted to a hyperacute stroke unit.J Neurol Neurosurg Psychiatry. 2017; 88: 2-6
- Factitious disorders and malingering: challenges for clinical assessment and management.Lancet. 2014; 383: 1422-1432
- Legal barriers to the growth of health information exchange-boulders or pebbles?.Milbank Q. 2018; 96: 110-143
- Report to Congress on Health IT Progress: Examining the HITECH Era and the Future of Health IT.Department of Health and Human Services, Washington, DC2016 (Available at:)https://www.healthit.gov/sites/default/files/2016_report_to_congress_on_healthit_progress.pdfDate accessed: September 24, 2019
- Care everywhere, a point-to-point HIE tool: utilization and impact on patient care in the ED.Appl Clin Inform. 2014; 5: 388-401
- Ethical challenges in acute evaluation of suspected psychogenic stroke mimics.J Clin Ethics. 2018; 29: 185-190
- Comorbid psychiatric disease is associated with lower rates of thrombolysis in ischemic stroke.Stroke. 2018; 49: 738-740
Article info
Publication history
Published online: December 02, 2019
Accepted:
October 13,
2019
Received in revised form:
October 7,
2019
Received:
June 21,
2019
Footnotes
Dr. Liberman receives research support from National Institutes of Health, United States grant K23NS107643.
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.