Advertisement
Original Contributions| Volume 58, ISSUE 6, P857-863, June 2020

Reducing Pain During Emergency Arterial Sampling Using Three Anesthetic Methods: A Randomized Controlled Clinical Trial

      Abstract

      Background

      Taking a sample of arterial blood is widely reported as a cause of significant pain.

      Objectives

      To compare three anesthetic methods with standard practice (no anesthesia) to establish which was the most effective in reducing pain caused by radial artery puncture in patients requiring an arterial blood gas test in the emergency department (ED).

      Methods

      A randomized controlled trial was conducted to compare the effectiveness between anesthetic cream, cryoanalgesia, and subcutaneous mepivacaine in reducing pain caused by radial artery puncture in ED patients.

      Results

      After comparing perceived pain during arterial puncture, the lowest median score was obtained in the mepivacaine group (1 interquartile range 0.6–1.3) and the highest median score in the control group (5 interquartile range 4.0–7.0). When comparing the control group with the three intervention groups, the Kruskal-Wallis test showed that mepivacaine (p = 0.023) and cryoanalgesia (p = 0.012) were associated with significantly lower pain scores. The anesthetic cream (p = 0.861) intervention group did not produce a statistically significant median difference compared with the control group.

      Conclusions

      The results of this study encourage the use of anesthetic methods like cryoanalgesia or mepivacaine for their proven effectiveness in reducing or eliminating pain during arterial puncture.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of Emergency Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Melanson S.E.F.
        • Szymanski T.
        • Rogers S.O.
        • et al.
        Utilization of arterial blood gas measurements in a large tertiary care hospital.
        Am J Clin Pathol. 2007; 127: 604-609
        • Brennan F.
        • Carr D.
        • Cousins M.
        Access to pain management-still very much a human right.
        Pain Med. 2016; 17: 1785-1789
        • Cooney M.F.
        • Czarnecki M.
        • Dunwoody C.
        • et al.
        American Society for Pain Management nursing position statement with clinical practice guidelines: authorized agent controlled analgesia.
        Pain Manag Nurs. 2013; 14: 176-181
        • Czarnecki M.L.
        • Turner H.N.
        • Collins P.M.
        • Doellman D.
        • Wrona S.
        • Reynolds J.
        Procedural pain management: a position statement with clinical practice recommendations.
        Pain Manag Nurs. 2011; 12: 95-111
        • World Health Organization (WHO)
        WHO guidelines on drawing blood: best practices in phlebotomy.
        WHO, Geneva, Switerland2010
        • Matheson L.
        • Stephenson M.
        • Huber B.
        Reducing pain associated with arterial punctures for blood gas analysis.
        Pain Manag Nurs. 2014; 15: 619-624
        • Joly L.M.
        • Spaulding C.
        • Monchi M.
        • Ali O.S.
        • Weber S.
        • Benhamou D.
        Topical lidocaine-prilocaine cream (EMLA®) versus local infiltration anesthesia for radial artery cannulation.
        Anesth Analg. 1998; 87: 403-406
        • Wade R.G.
        • Crawfurd J.
        • Wade D.
        • Holland R.
        Radial artery blood gas sampling: a randomized controlled trial of lidocaine local anesthesia.
        J Evid Based Med. 2015; 8: 185-191
        • Zinchenko R.
        • Prinsloo N.J.
        • Zarafov A.
        • Grzesiak M.
        • Cohn A.
        More needles less pain: the use of local anaesthesia during emergency arterial sampling.
        J Acute Dis. 2016; 5: 244-247
        • Hudson T.L.
        • Dukes S.F.
        • Reilly K.
        Use of local anesthesia for arterial punctures.
        Am J Crit Care. 2006; 15: 595-599
        • Aguilar X.
        • Olona M.
        • Janer D.
        • Rodríguez E.
        • Canadell L.
        • Perelló S.
        Efficacy of Emla® anesthetic cream compared to placebo for the prevention of pain in radial artery puncture in patients with chronic respiratory pathology.
        Aten Farm. 2007; 9: 254-260
        • France J.E.
        • Beech F.J.M.
        • Jakeman N.
        • Benger J.R.
        Anaesthesia for arterial puncture in the emergency department: a randomized trial of subcutaneous lidocaine, ethyl chloride or nothing.
        Eur J Emerg Med. 2008; 15: 218-220
        • Haynes J.M.
        Randomized controlled trial of cryoanalgesia (ice bag) to reduce pain associated with arterial puncture.
        Respir Care. 2015; 60: 1-5
        • Bastami M.
        • Azadi A.
        • Mayel M.
        The use of ice pack for pain associated with arterial punctures.
        J Clin Diagn Res. 2015; 9: JC07-JC09
        • Page D.E.
        • Taylor D.M.D.
        Vapocoolant spray vs subcutaneous lidocaine injection for reducing the pain of intravenous cannulation: a randomized, controlled, clinical trial.
        Br J Anaesth. 2010; 105: 519-525
        • Karcioglu O.
        • Topacoglu H.
        • Dikme O.
        • Dikme O.
        A systematic review of the pain scales in adults: which to use?.
        Am J Emerg Med. 2018; 36: 707-714
        • Ruyssen-Witrand A.
        • Tubach F.
        • Ravaud P.
        Systematic review reveals heterogeneity in definition of a clinically relevant difference in pain.
        J Clin Epidemiol. 2011; 64: 463-470
        • Hajiseyedjavady H.
        • Saeedi M.
        • Eslami V.
        • Shahsavarinia K.
        • Farahmand S.
        Less painful arterial blood gas sampling using jet injection of 2% lidocaine: a randomized controlled clinical trial.
        Am J Emerg Med. 2012; 30: 1100-1104
        • Sawynok J.
        Topical analgesics.
        in: Lynch M.E. Craig K.D. Peng P.W.H. Clinical pain management: a practical guide. Blackwell Publishing Ltd, Chichester, UK2011: 135-141
        • Aaron S.D.
        • Vandemheen K.L.
        • Naftel S.A.
        • Lewis M.J.
        • Rodger M.A.
        Topical tetracaine prior to arterial puncture: a randomized, placebo-controlled clinical trial.
        Respir Med. 2003; 97: 1195-1199

      Linked Article

      • Pain Relief in Arterial Sampling
        Journal of Emergency MedicineVol. 60Issue 3
        • Preview
          I have read with interest the recent article, “Reducing Pain During Emergency Arterial Sampling Using Three Anesthetic Methods: A Randomized Controlled Clinical Trial” by Nicola Pagnucci et al. (1). This article is a well-designed randomized controlled trial and very important for emergency departments (EDs) and intensive care units. Although pain is the most common reason to apply to EDs, administration of analgesics is delayed or adequate pain medication is not applied in procedural interventions (2,3).
        • Full-Text
        • PDF