A 63-year-old man presents with a recent diagnosis of depression and a sleep disorder,
complaining of “anxiety.” His medication had recently been changed to sertraline (Zoloft;
Pfizer, New York, NY) 50 mg by his primary care provider (PCP). After taking his first
morning dosage, he reported feeling progressive anxiety and restlessness. He described
the anxiety as severe, constant, and not relieved or worsened by anything. His review
of systems was negative for visual and auditory hallucinations, and he denied any
suicidal or homicidal ideations.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Emergency MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The syndrome of motor restlessness--a treatable but under-recognised disorder.Postgrad Med J. 1997; 73: 529-530
- [Three cases of drug-induced akathisia due to antiemetics during cancer palliative care].Gan To Kagaku Ryoho. 2006; 33 ([in Japanese]): 267-269
- Selective serotonin reuptake inhibitor-induced akathisia.J Am Pharm Assoc (2003). 2009; 49 (quiz e37–8): e28-e36
- A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats.Arq Neuropsiquiatr. 1992; 50: 263-268
- Levodopa-induced dyskinesias in Parkinson's disease phenomenology and pathophysiology.Mov Disord. 1994; 9: 2-12
- Lithium-induced akathisia responds to low-dose mianserin: case report.Int Clin Psychopharmacol. 1995; 10: 261-263
- The management of psychiatric emergencies.Dtsch Arztebl Int. 2011; 13: 222-230
- SSRI-induced extrapyramidal side-effects and akathisia: implications for treatment.J Psychopharmacol. 1998; 12: 192-214
- Revisiting antipsychotic-induced akathisia: current issues and prospective challenges.Curr Neuropharmacol. 2017; 15: 789-798
- Increased anxiety, akathisia, and suicidal thoughts in patients with mood disorder on aripiprazole and lamotrigine.Case Rep Psychiatry. 2015; 2015: 419746
- Case presentation and review of newer treatment agents.Psychiatr Ann. 2014; 44: 391-396
- Akathisia.(Available at:)https://www.webmd.com/schizophrenia/what-is-akathisia#2Date accessed: April 22, 2020
- A rating scale for drug-induced akathisia.Br J Psychiatry. 1989; 154: 672-676
- The mechanism of drug-induced akathsia.CNS Spectr. 2011; ([Epub ahead of print])
- Lesson of the week: akathisia: overlooked at a cost.BMJ. 2002; 324: 1506-1507
- Acute antipsychotic-induced akathisia revisited.Br J Psychiatry. 2010; 196: 89-91
- Restless legs syndrome and akathisia as manifestations of acute pontine infarction.J Clin Neurosci. 2014; 21: 354-355
- Common comorbidities and differential diagnosis of restless legs syndrome.(Available at:)http://www.cmeinstitute.com/Activities/Pages/neurologyreports/rls/ondo.aspx#Date accessed: April 22, 2020
- Anxiety disorders in elderly patients.J Am Board Fam Pract. 1997; 10: 280-289
- Distinguishing akathisia and tardive dyskinesia: a review of the literature.J Clin Psychopharmacol. 1983; 3: 343-350
- The Withdrawal Project. Withdrawal-induced akathisia: quick tips.(Available at:)https://withdrawal.theinnercompass.org/coping/withdrawal-induced-akathisia-quick-tipsDate: 2018Date accessed: April 22, 2020
- Akathisia or anxiety: what is the difference?.Am J Geriatr Psychiatry. 2017; 25: S82-S83
- Diphenhydramine in the treatment of akathisia induced by prochlorperazine.J Emerg Med. 2004; 26: 265-270
- Extrapyramidal adverse effects associated with sertraline.Prog Neuropsychopharmacol Biol Psychiatry. 1998; 22: 741-748
- Acute and tardive drug-induced akathisia.in: Sethi K.D. Drug-induced movement disorders. CRC Press, Boca Raton, FL2004: 129-164
- The causes of underdiagnosing akathisia.Schizophr Bull. 2003; 29: 547-558
- Benzodiazepines for neuroleptic-induced acute akathisia.Cochrane Database Syst Rev. 2002; 1: CD001950
- Acute akathisia.in: Friedman J.H. Medication-induced movement disorders. Cambridge University Press, Cambridge, UK2015: 3-19
- Extrapyramidal reactions associated with serotonergic antidepressants.Ann Pharmacother. 2015; 49: 1136-1152
- Randomized, double-blind, crossover, placebo-controlled comparison of propranolol and betaxolol in the treatment of neuroleptic-induced akathisia.Am J Psychiatry. 1992; 149: 647-650
- The incidence of akathisia in the treatment of schizophrenia with aripiprazole, asenapine and lurasidone: a meta-analysis.Curr Neuropharmacol. 2015; 13: 681-691
- A case of akathisia induced by escitalopram: case report & review of literature.Curr Drug Saf. 2014; 9: 56-59
Article info
Publication history
Published online: April 30, 2020
Accepted:
March 20,
2020
Received in revised form:
February 19,
2020
Received:
July 21,
2017
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.