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Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomized controlled, open label, non-inferiority study

Stahlgren GS, Tyrstrup M, Edlund C, et al. BMJ. 2019; 367:I5337.
      Acute tonsillitis and pharyngitis are common reasons that many patients present to receive medical care. Due to the lack of production of new antibiotics and growing resistance patterns, optimizing antibiotic use is paramount, especially in a condition where there are many patients being treated for the condition with a singular agent. The purpose of this study was to evaluate whether a more frequent and shorter duration of antibiotic treatment was non-inferior to the traditional three times daily treatment for 10 days.
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