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Effect of selepressin vs placebo on ventilator- and vasopressor-free days in patients with septic shock: The SEPSIS-ACT randomized clinical trial

Laterre PF, Berry SM, Blemings A, et al. JAMA. 2019; 322:1476-1485.
      Septic shock is a life-threatening condition requiring the use of medications for blood pressure support. The first-line medication norepinephrine is often insufficient in restoring adequate blood pressure. Vasopressin is often used as an adjunct for blood pressure support, but each of these medications has adverse effects. Therefore, interest in alternative agents has led to evaluation of medications such as selepressin, a selective vasopressin V1a receptor agonist.
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