The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study

Saeed K, Wilson DC, Bloos F, et al. Critical Care. 2019;23(40).
      The early identification of sepsis is a national focus in emergency medicine. The clinician toolbox currently contains biomarkers and clinical scores to help aid in deciding the likelihood of the presence of infection and corresponding severity. These biomarkers include procalcitonin (PCT), lactate, and c-reactive protein (CRP). Clinical scoring tools include the Systemic Inflammatory Response Syndrome (SIRS) score, Sequential Organ Failure Assessment (SOFA) score, and quick SOFA (qSOFA) score. The authors of the study address the utility of these biomarkers and scoring tools, in addition to a newer novel biomarker, mid-regional proadrenomedullin (MR-proADM), in patients presenting to the emergency department with suspected infection, with a more specific aim to identify those at risk for disease progression and mortality versus patients with uncomplicated infections appropriate for out-patient treatment.
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