The early identification of sepsis is a national focus in emergency medicine. The
clinician toolbox currently contains biomarkers and clinical scores to help aid in
deciding the likelihood of the presence of infection and corresponding severity. These
biomarkers include procalcitonin (PCT), lactate, and c-reactive protein (CRP). Clinical
scoring tools include the Systemic Inflammatory Response Syndrome (SIRS) score, Sequential
Organ Failure Assessment (SOFA) score, and quick SOFA (qSOFA) score. The authors of
the study address the utility of these biomarkers and scoring tools, in addition to
a newer novel biomarker, mid-regional proadrenomedullin (MR-proADM), in patients presenting
to the emergency department with suspected infection, with a more specific aim to
identify those at risk for disease progression and mortality versus patients with
uncomplicated infections appropriate for out-patient treatment.
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