Sepsis is associated with up to half of all in-hospital deaths. The administration
of intravenous (IV) hydrocortisone, thiamine, and vitamin C has been suggested to
improve mortality rates in patients with septic shock compared to those who received
hydrocortisone alone, but the number of patients studied and the methods of previous
studies have been scrutinized. The authors of this multi-center, randomized control
trial aimed to determine if there is a significant difference in mortality and vasopressor
requirements in patients with septic shock between hydrocortisone monotherapy and
hydrocortisone therapy plus the addition of intravenous vitamin C and thiamine.
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