Sepsis is associated with up to half of all in-hospital deaths. The administration of intravenous (IV) hydrocortisone, thiamine, and vitamin C has been suggested to improve mortality rates in patients with septic shock compared to those who received hydrocortisone alone, but the number of patients studied and the methods of previous studies have been scrutinized. The authors of this multi-center, randomized control trial aimed to determine if there is a significant difference in mortality and vasopressor requirements in patients with septic shock between hydrocortisone monotherapy and hydrocortisone therapy plus the addition of intravenous vitamin C and thiamine.
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