Intravenous fluid (IVF) administration is a key component in the treatment of diabetic
ketoacidosis (DKA). Normal saline is currently the primary fluid recommended by clinical
practice guidelines for the treatment of DKA; however, it has been shown to cause
a hyperchloremic metabolic acidosis due to its high chloride concentration when compared
to human plasma. Balanced crystalloid solutions, like Lactated Ringer’s (LR) and Plasma-Lyte
A (Baxter Inc), do not cause a metabolic acidosis as their chloride concentrations
are similar to human plasma. Considering this information, treatment with balanced
crystalloids may lead to faster resolution of DKA. The objective of this study was
to compare the clinical effects of balanced crystalloid with those of saline for the
acute treatment of DKA.
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