Abstract
Background
Chronic kidney disease (CKD) is associated with a higher mortality rate and a poor
prognosis among patients with acute ischemic stroke (AIS) who receive intravenous
thrombolysis (IVT); however, it is still unclear whether IVT improves the prognosis
of patients with AIS and CKD.
Objective
We conducted this study to evaluate the impact of IVT in patients with AIS and CKD.
Methods
We analyzed patients with AIS and CKD in 3 stroke centers who met the indications
for IVT between January 2015 and January 2020. The patients were grouped into an IVT
group and a non-IVT group according to whether patients received IVT. After propensity
score matching at a 1:1 ratio, symptomatic intracranial hemorrhage (sICH) and the
modified Rankin Scale (mRS) score at 3 months were compared to assess the safety and
efficacy of IVT in patients with AIS with CKD.
Results
A total of 888 patients were enrolled: 763 in the IVT group and 125 in the non-IVT
group. After matching, 250 patients were analyzed, and no significant differences
were found in sICH between the 2 groups. However, the IVT group had a better 90-day
mRS (0–2) score (70.4% vs. 57.6; p = 0.048) than the non-IVT group.
Conclusions
IVT improved the 3-month prognosis and did not increase the occurrence of sICH among
patients with AIS with CKD.
Keywords
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Article info
Publication history
Published online: May 13, 2022
Accepted:
May 9,
2022
Received in revised form:
March 24,
2022
Received:
December 16,
2021
Identification
Copyright
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