Highlights
- •Bleeding caused by anticoagulants or coagulopathies is a challenging scenario
- •Timely selection of treatment strategies is highly important
- •Five tables provide guidance when treating emergent bleeding
Abstract
Background
Reversal of antithrombotic agents and treatment of life-threatening bleeding episodes
from coagulopathies can be a stressful scenario for clinicians, especially when the
selection of treatment options should occur quickly. Understanding the options available
for these agents requires emergency physicians to be familiar with the current data
surrounding new therapies and dosing strategies for the treatment of bleeding from
reversible and nonreversible antithrombotics and coagulopathic conditions.
Objective
To provide quick resource guides for the reversal of major or life-threatening bleeding
caused by antithrombotic agents or in the setting of coagulopathies.
Methods
A literature search for articles published through September 2021 related to antithrombotic
reversal and treatment of acute bleeding from coagulopathies was conducted using the
PubMed clinical database. Selected articles were used to generate 5 guidance tables
in this clinical review.
Discussion
Four guidance tables for how to treat major or life-threatening bleeding from antithrombotic
agents and 1 table for how to manage life-threatening bleeding for coagulopathies
are presented as a quick reference tool for the emergency physician. Additional information
on upcoming reversal agents and possible treatment options are provided herein.
Conclusions
In this clinical review, a series of 5 tables were created to provide quick and comprehensive
guidance for the emergency physician when treating major or life-threatening bleeding
caused by antithrombotic agents or coagulopathies. © 2022 Elsevier Inc.
Keywords
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Article info
Publication history
Published online: May 12, 2022
Accepted:
May 9,
2022
Received in revised form:
April 29,
2022
Received:
January 7,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
