Published:December 26, 2022DOI:



      The emerging 2022 human monkeypox (MPX) virus outbreak has presented with unique disease manifestations challenging prior case definitions.

      Case Report

      We present a case of a 42-year-old transgender woman with human immunodeficiency virus controlled on antiretroviral therapy, presenting with sore throat, who, after three emergency department visits, was found to have acute tonsillitis complicated by airway obstruction secondary to MPX. Why Should an Emergency Physician Be Aware of This? Sore throat is a common presentation to the emergency department. MPX should be placed on the list of differential diagnoses when evaluating patients who present with pharyngitis to avoid complications or a missed diagnosis.


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