Alcohol is the most-used intoxicant in the world, and the repercussions of unhealthy
alcohol use are of corresponding magnitude. A six-fold increase in all-cause mortality
and six percent of overall deaths are related to the use of alcohol, (1,2) which is
the most important risk factor for ill health among working-age people worldwide.
(3) Alcohol intoxication (AI) is strongly tied to serious trauma (especially motor
vehicle collisions (4)), suicide, (5) domestic abuse and sexual assault, crime, (6)
and thousands of Americans die from alcohol poisoning every year. (7) In addition
to the myriad medical consequences of chronic alcohol use, addiction to alcohol–suffered
by over 14 million Americans (8)–leads to the destruction of relationships, families
and social function, including unemployment and homelessness. Mortality among patients
with AUD increased by over 20% in 2020 and 2021, during the COVID-19 pandemic. (9,10)
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Article info
Publication history
Accepted:
January 6,
2023
Received:
October 28,
2022
Publication stage
In Press Accepted ManuscriptIdentification
Copyright
© 2023 Elsevier Inc. All rights reserved.
