We read with interest the article “Do Higher Doses of Naloxone Increase the Risk of
Pulmonary Complications?” by Acus et al., as it attempted to answer an important clinical
question (
1
). The article aimed to examine the effect of increasing doses of naloxone and its
relationship to pulmonary complications in the setting of opioid toxicity. Because
the opioid epidemic has been fueled by synthetic opioids (i.e., fentanyl and fentanyl
analogs) and reports of “naloxone resistance” have occurred, understanding proper
naloxone dosing and potential risks is critical (
2
).To read this article in full you will need to make a payment
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References
- Do higher doses of naloxone increase the risk of pulmonary complications?.J Emerg Med. 2023; 64 (00–00)
- Characteristics of fentanyl overdose - Massachusetts, 2014-2016.MMWR Morb Mortal Wkly Rep. 2017; 66: 382-386
- A phase I trial of naloxone treatment in acute spinal cord injury.J Neurosurg. 1985; 63: 390-397
- A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study.N Engl J Med. 1990; 322: 1405-1411
- Physiological effects of high dose naloxone administration to normal adults.Life Sci. 1982; 30: 2025-2031
- Biostatistics and epidemiology for the toxicologist: incidence and prevalence.J Med Toxicol. 2022; 18: 56-57
- Oedema of the left lung-morphia poisoning.Montreal Gen Hosp Rep. 1880; 1: 291
Article info
Publication history
Published online: March 04, 2023
Accepted:
February 23,
2023
Received:
November 29,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Elsevier Inc. All rights reserved.
